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Meta-analysis
ACE Report #10449
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Gabapentinoids, topiramate do not demonstrate significant effect on pain and disability in LBP


Study Type:N/A
OE Level Evidence:2
Journal Level of Evidence:N/A

Anticonvulsants in the treatment of low back pain and lumbar radicular pain: a systematic review and meta-analysis

CMAJ. 2018 Jul 3;190(26):E786-E793. doi: 10.1503/cmaj.171333

Contributing Authors: CG Maher J Latimer AJ McLachlan S Mathieson O Enke HA New CH New CC Lin

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Synopsis

Nine randomized controlled trials were included in the meta-analysis and systematic review, which was conducted to analyze the effects of anticonvulsants - including gabapentinoids and topiramate - in patients with either nonspecific low back pain or lumbar radicular pain secondary to spinal stenosis. Results on gabapentinoids demonstrated no significant differences relative to placebo on either p...

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