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Dronabinol is not better than placebo for ALS cramps and fasciculations over 2 weeks
October 2018
Dronabinol is not better than placebo for ALS cramps and fasciculations over 2 weeks
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A
Tetrahydrocannabinol (THC) for cramps in amyotrophic lateral sclerosis: a randomised, double-blind crossover trial
J Neurol Neurosurg Psychiatry. 2010 Oct;81(10):1135-40. doi: 10.1136/jnnp.2009.200642Synopsis
27 patients with amyotrophic lateral sclerosis (ALS) were randomized to receive either 5 mg dronabinol twice daily or placebo for 2 weeks in a randomized sequence. The purpose of this study was to determine if dronabinol decreases frequency and intensity of cramps and fasciculations compared to placebo, and if there are any improvements in sleep quality, functional ability, appetite and depression...
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