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Volume:7 Issue:9 Number:24 ISSN#:2564-2537
RCT
ACE Report #10383
Ace Report Cover Cannabis

Tetrahydrocannabinol 8mg does not demonstrate better efficacy vs diazepam for chronic pancreatitis


How to Cite

OrthoEvidence. Tetrahydrocannabinol 8mg does not demonstrate better efficacy vs diazepam for chronic pancreatitis. ACE Report. 2018;7(9):24. Available from: https://myorthoevidence.com/AceReport/Report/10383

Study Type:Randomized Trial
OE Level Evidence:2
Journal Level of Evidence:N/A

Single dose delta-9-tetrahydrocannabinol in chronic pancreatitis patients: Analgesic efficacy, pharmacokinetics and tolerability

Br J Clin Pharmacol. 2016 Mar;81(3):525-37. doi: 10.1111/bcp.12811

Contributing Authors: M de Vries DCM van Rijckevorsel KCP Vissers OHG Wilder-Smith H van Goor

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Synopsis

22 patients with chronic pancreatitis took 8 mg of delta-9-tetrahydrocannbinol (Δ9-THC) with placebo diazepam or placebo Δ9-THC with diazepam at 2 sessions in a randomly allocated sequence for this crossover trial. Blood samples were examined for the pharmacokinetic and pharmacodynamic properties of Δ9-THC, and reduction in pain was measured by the VAS scale. Bond and Lader visual analogue scales ...

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