Oral tetrahydrocannabinol (THC) does not reduce chronic abdominal pain compared to placebo

How to Cite

OrthoEvidence. Oral tetrahydrocannabinol (THC) does not reduce chronic abdominal pain compared to placebo. ACE Report. 2018;7(9):22. Available from: https://myorthoevidene.com/AceReport/Report/10376

Study Type:Therapy

OE Level Evidence:1

Journal Level of Evidence:N/A

Tetrahydrocannabinol Does Not Reduce Pain in Patients With Chronic Abdominal Pain in a Phase 2 Placebo-controlled Study

Clin Gastroenterol Hepatol. 2017 Jul;15(7):1079-1086.e4. doi: 10.1016/j.cgh.2016.09.147

Contributing Authors: M de Vries DCM van Rijckevorsel KCP Vissers OHG Wilder-Smith H van Goor Group Pain and Nociception Neuroscience Research

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Synopsis

65 patients with chronic abdominal pain following surgery or due to chronic pancreatitis were randomized to receive delta-9-tetrahydrocannabinol (THC) or placebo for 50-52 days. The primary outcome was pain relief, as measured by a visual analogue scale (VAS). Secondary outcomes included other measures of pain, depression, anxiety, quality of life, treatment satisfaction, appetite, alertness, mood...