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Volume:7 Issue:10 Number:46 ISSN#:2564-2537
ACE Report #10365
Ace Report Cover Cannabis

Cannabis oralmucosal spray does not significantly improve neuropathic pain from multiple sclerosis

How to Cite

OrthoEvidence. Cannabis oralmucosal spray does not significantly improve neuropathic pain from multiple sclerosis. ACE Report. 2018;7(10):46. Available from: https://myorthoevidence.com/AceReport/Report/10365

Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

A double-blind, randomized, placebo-controlled, parallel-group study of THC/CBD oromucosal spray in combination with the existing treatment regimen, in the relief of central neuropathic pain in patients with multiple sclerosis

J Neurol. 2013 Apr;260(4):984-97. doi: 10.1007/s00415-012-6739-4

Contributing Authors: S Ratcliffe W Notcutt RM Langford J Mares A Novotna M Vachova I Novakova

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In a multicentre randomized trial, 339 patients with central neuropathic pain due to multiple sclerosis (MS) were randomized to receive either an oralmucosal spray containing THC and CBD (nabiximols) or placebo spray for 12 weeks, followed by an open-label and randomized-withdrawal phase for another 14 weeks. The primary outcome was at least 30% pain reduction, and secondary outcomes included time...

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