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ACE Report #10339
Ace Report Cover Arthroplasty

Large-scale trial comparing topical and intravenous TXA efficacy in total knee arthroplasty

Study Type:N/A
OE Level Evidence:2
Journal Level of Evidence:1

Intravenous Versus Topical Tranexamic Acid in Total Knee Arthroplasty: Both Effective in a Randomized Clinical Trial of 640 Patients

J Bone Joint Surg Am. 2018 Jun 20;100(12):1023-1029

Contributing Authors: RT Trousdale EP Su F Boettner MP Figgie DJ Mayman SB Haas MJ Taunton MP Abdel YY Lee RJ Sierra M Pagano BP Chalmers

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664 patients scheduled for total knee arthroplasty were randomized to either topical tranexamic acid or intravenous tranexamic acid. Patients were assessed for total blood loss, postoperative blood loss, and the incidence of transfusion. Results demonstrated that despite the statistically significantly lower total and postoperative blood loss in the intravenous group, there was no significant diff...

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