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RCT
ACE Report #10174
Ace Report Cover Osteoarthritis

Nonopioid analgesia demonstrates better 12-month efficacy versus opioids for chronic OA pain and LBP


Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

Effect of Opioid vs Nonopioid Medications on Pain-Related Function in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain: The SPACE Randomized Clinical Trial

JAMA. 2018 Mar 6;319(9):872-882

Contributing Authors: K Kroenke EE Krebs MJ Bair A Gravely S Nugent AC Jensen B DeRonne ES Goldsmith S Noorbaloochi

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Synopsis

240 patients with moderate-to-severe chronic low back pain, knee osteoarthritis pain, or hip osteoarthritis pain were randomized to analgesia through either an opioid or nonopioid medication regimen. Patients were assessed over 12-month follow-up for efficacy outcomes related to pain-related function, pain severity, quality-of-life and disability, and safety outcomes related to adverse events and ...

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