Nonopioid analgesia demonstrates better 12-month efficacy versus opioids for chronic OA pain and LBP
Effect of Opioid vs Nonopioid Medications on Pain-Related Function in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain: The SPACE Randomized Clinical TrialJAMA. 2018 Mar 6;319(9):872-882
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240 patients with moderate-to-severe chronic low back pain, knee osteoarthritis pain, or hip osteoarthritis pain were randomized to analgesia through either an opioid or nonopioid medication regimen. Patients were assessed over 12-month follow-up for efficacy outcomes related to pain-related function, pain severity, quality-of-life and disability, and safety outcomes related to adverse events and ...
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