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RCT
ACE Report #10109
Ace Report Cover Arthroplasty

Similar extended VTE prophylaxis efficacy and safety between rivaroxaban and aspirin following TJA


Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

Aspirin or Rivaroxaban for VTE Prophylaxis after Hip or Knee Arthroplasty

N Engl J Med. 2018 Feb 22;378(8):699-707

Contributing Authors: PA Vendittoli SJ MacDonald M Dunbar SR Kahn E Bohm S Pelet W Gofton DR Anderson E Belzile D Zukor W Fisher P Gross M Crowther P Kim S Pleasance P Andreou MA Rodger M Carrier J Murnaghan M Forsythe S Dolan S Doucette C Theriault A Abianui MJ Kovacs D Coyle PS Wells

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Synopsis

3427 patients who had undergone either total knee or hip arthroplasty with a 5-day course of rivaroxaban 10mg postoperatively were randomized to extended thromboprophylaxis with either aspirin 81mg daily or continued rivaroxaban 10mg daily. Patients were assessed for the incidence of venous thromboembolism, major bleeding events, and clinically relevant nonmajor bleeding events over the first 90 d...

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