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Meta-analysis
ACE Report #10107
Ace Report Cover General Orthopaedics

No significant difference in the incidence of VTE between IV TXA and control in orthopaedic surgery


Study Type:Meta analysis
OE Level Evidence:1
Journal Level of Evidence:N/A

Safety of intravenous tranexamic acid in patients undergoing major orthopaedic surgery: a meta-analysis of randomised controlled trials

Blood Transfus. 2018 Jan;16(1):36-43

Contributing Authors: M Franchini C Mengoli M Marietta G Marano S Vaglio S Pupella PM Mannucci GM Liumbruno

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Synopsis

73 randomized controlled trials were included in this meta-analysis investigating the incidence of venous thromboembolic complications between patients administered intravenous tranexamic acid and patients who were not administered TXA. Meta-analysis demonstrated no significant difference between IV TXA groups and control groups in the incidence of VTE complications, which were estimated at 2.1% a...

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