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Meta-analysis
ACE Report #10087
Ace Report Cover Arthroplasty

IA-TXA effective compared to placebo for blood loss and transfusion reduction in TKA


Study Type:Meta analysis
OE Level Evidence:2
Journal Level of Evidence:N/A

Intra-articular Tranexamic Acid in Primary Total Knee Arthroplasty: Meta-analysis

J Knee Surg. 2018 Jan;31(1):56-67

Contributing Authors: JT Moskal SG Capps

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Synopsis

Sixteen studies were included in this meta-analysis, which compared the effect of intra-articular tranexamic acid to placebo for outcomes related to blood loss, transfusion rate, and adverse events. Pooled analyses demonstrated significant differences in favour of IA-TXA for all efficacy outcomes, including total blood loss, postoperative blood loss, transfusion rate, and hemoglobin drop. Rates of...

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