Comparing efficacy of intraarticular single crosslinked Hyaluronan (HYAJOINT Plus) and platelet-rich plasma (PRP) versus PRP alone for treating knee osteoarthritis

この研究はインパクトが大きい可能性があると判断されました。 OEのAIによるハイインパクト指標は、論文が掲載されたジャーナルと論文自体の科学的内容の両方からのシグナルを統合することで、論文の影響力を推定します。 最先端の自然言語処理を用いて開発されたOEハイインパクトモデルは、ジャーナルのインパクトファクターのみよりも、研究の将来の引用実績をより正確に予測します。 これにより、臨床的に意義のある研究をより早く認識することができ、読者は将来の診療を形成する可能性が最も高い論文に焦点を当てることができます。

研究概要

Eighty-five patients with symptomatic knee osteoarthritis (OA) were randomized to receive 2 injections consisting of a single intra-articular injection of hyaluronic acid (HA) followed by platelet-rich plasma (PRP; n=43) or the single injection group consisting of PRP alone (n=42). The primary outcome of interest was pain evaluated using the Visual Analogue Scale (VAS) at 1,3, and 6-months follow-up. Secondary outcomes of interest included the following: the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and its associated subscales (pain, stiffness, and function), Lequesne index, single leg stance test (SLS), patient satisfaction, and usage of acetaminophen which all secondary outcomes were evaluated at 1, 3, and 6-months follow-up. Results of this study demonstrated that VAS was statistically significantly improved at 6-months follow-up in the combined injection group vs PRP alone (p=0.020). For secondary outcomes, WOMAC function and total scores, Lequesne Index, SLS, and patient satisfaction scores were not statistically significantly different between 2 groups at all timepoints (p>0.05). However, WOMAC pain and stiffness were both statistically significantly higher in the combined injection group vs PRP alone at 1-month follow-up (p=0.025, p=0.011; respectively). Furthermore, the consumption of analgesics was not statistically significantly different between both groups (p>0.05).