TKA: No benefit of spray-application PRP for wound healing, pain, and function .
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2013;1(5):9 Acta Orthop. 2009 Oct;80(5):557-62. doi: 10.3109/17453670903350081102 patients scheduled for total knee arthroplasty due to osteoarthritis of the knee were randomized to determine the efficacy of autologous blood platelet concentrate on wound healing following surgery. Patients were allocated to receive a spray application of platelet-rich plasma (PRP) to the wound site prior to closure or to a control group receiving no PRP application. Follow-up was conducted for up to 3 months post-operatively for outcomes of wound healing, pain, and function. Wound healing at 2 weeks was found to be significantly better in the control group, with a higher proportion of control patients achieving total closure. Patients who received PRP also displayed no benefits in regards to pain and function.
Was the allocation sequence adequately generated?
Was allocation adequately concealed?
Blinding Treatment Providers: Was knowledge of the allocated interventions adequately prevented?
Blinding Outcome Assessors: Was knowledge of the allocated interventions adequately prevented?
Blinding Patients: Was knowledge of the allocated interventions adequately prevented?
Was loss to follow-up (missing outcome data) infrequent?
Are reports of the study free of suggestion of selective outcome reporting?
Were outcomes objective, patient-important and assessed in a manner to limit bias (ie. duplicate assessors, Independent assessors)?
Was the sample size sufficiently large to assure a balance of prognosis and sufficiently large number of outcome events?
Was investigator expertise/experience with both treatment and control techniques likely the same (ie.were criteria for surgeon participation/expertise provided)?
Sí = 1
Incierto = 0,5
No relevante = 0
No = 0
La evaluación de los criterios de información evalúa la transparencia con la que los autores informan de las características metodológicas y del ensayo dentro de la publicación. La evaluación se divide en cinco categorías que se presentan a continuación.
3/4
Randomization
3/4
Outcome Measurements
2/4
Inclusion / Exclusion
4/4
Therapy Description
4/4
Statistics
Detsky AS, Naylor CD, O'Rourke K, McGeer AJ, L'Abbé KA. J Clin Epidemiol. 1992;45:255-65
El Índice de Fragilidad es una herramienta que ayuda en la interpretación de hallazgos significativos, proporcionando una medida de fuerza para un resultado. El Índice de Fragilidad representa el número de eventos consecutivos que es necesario añadir a un resultado dicotómico para que el hallazgo deje de ser significativo. Un número pequeño representa un hallazgo más débil y un número grande un hallazgo más fuerte.
¿Por qué se necesitaba ahora este estudio?
Accelerated wound healing following total knee arthroplasty (TKA) is beneficial, allowing for the possibility of greater functional outcomes. Accordingly, there has been recent interest in researching methods to enhance healing following surgery, which has brought popularity to platelet concentrates and related products. The high concentration of growth factors sourced from platelets has been reported to enhance tissue repair and bone formation in a number of interventions. However, high quality clinical investigations to demonstrate efficacy of autologous blood platelet concentrate in TKA are still required.
¿Cuál era la pregunta principal de la investigación?
In adult patients undergoing TKA, what is the effect of autologous blood platelet concentrate on wound healing, knee function, and analgesic requirement at 3 month follow-up?
- Wound closure during hospitalization did not significantly differ between the two groups (POD3: P=0.5, 95%CI 7% (-11% to 25%); POD4: P=0.4, 95%CI 9% (-30% to 10%)).
- By two weeks post-operatively, the number of patients with total wound closure was significantly greater in the control group (16/46) compared to the PRP group (4/36) (P=0.02, 95%CI -24% (-41% to 7%)).
- Pain reduction at 6 weeks approached significance favoring the control group (At rest: P=0.08; During walking: P=0.07). However, difference in pain between groups diminished at 3-month follow-up (At rest: P=0.8; During walking: P=0.9).
- Frequency of pain medication use was similar between groups at both 6-week (P=0.9) and 3-month (P=0.1) follow-up evaluations.
- Functional outcomes did not significantly differ between groups: ROM evaluation (In hospital (POD 2-4): P=0.7; 3 months: P=0.9), and WOMAC score (6 weeks: P=0.7; 3 months: P=0.4).
¿Qué es lo que más debo recordar?
Spray application of platelet-rich plasma for total knee arthroplasty was not associated with any benefit in wound healing. Additionally, there was no beneficial effect of platelet-rich plasma treatment on pain, analgesia or functional outcome over 3-months.
¿Cómo afectará esto al cuidado de mis pacientes?
The findings of this study do not support the use of spray-applied autologous blood platelet concentrate in total knee arthroplasty due to the lack of efficacy in improving wound healing, pain, and function compared to control. Since there was significant loss of power to detect differences between groups as a result of the integration of two hospitals into one and the subsequent loss of data, results of this research should be considered only as indicative rather than conclusive.
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