TKA: No benefit of spray-application PRP for wound healing, pain, and function .
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2013;1(5):9 Acta Orthop. 2009 Oct;80(5):557-62. doi: 10.3109/17453670903350081102 patients scheduled for total knee arthroplasty due to osteoarthritis of the knee were randomized to determine the efficacy of autologous blood platelet concentrate on wound healing following surgery. Patients were allocated to receive a spray application of platelet-rich plasma (PRP) to the wound site prior to closure or to a control group receiving no PRP application. Follow-up was conducted for up to 3 months post-operatively for outcomes of wound healing, pain, and function. Wound healing at 2 weeks was found to be significantly better in the control group, with a higher proportion of control patients achieving total closure. Patients who received PRP also displayed no benefits in regards to pain and function.
Was the allocation sequence adequately generated?
Was allocation adequately concealed?
Blinding Treatment Providers: Was knowledge of the allocated interventions adequately prevented?
Blinding Outcome Assessors: Was knowledge of the allocated interventions adequately prevented?
Blinding Patients: Was knowledge of the allocated interventions adequately prevented?
Was loss to follow-up (missing outcome data) infrequent?
Are reports of the study free of suggestion of selective outcome reporting?
Were outcomes objective, patient-important and assessed in a manner to limit bias (ie. duplicate assessors, Independent assessors)?
Was the sample size sufficiently large to assure a balance of prognosis and sufficiently large number of outcome events?
Was investigator expertise/experience with both treatment and control techniques likely the same (ie.were criteria for surgeon participation/expertise provided)?
Oui = 1
Incertain = 0,5
Non pertinent = 0
Non = 0
L'évaluation des critères de rapport permet d'évaluer la transparence avec laquelle les auteurs rapportent les caractéristiques méthodologiques et les caractéristiques de l'essai dans la publication. L'évaluation est divisée en cinq catégories qui sont présentées ci-dessous.
3/4
Randomization
3/4
Outcome Measurements
2/4
Inclusion / Exclusion
4/4
Therapy Description
4/4
Statistics
Detsky AS, Naylor CD, O'Rourke K, McGeer AJ, L'Abbé KA. J Clin Epidemiol. 1992;45:255-65
L'indice de fragilité est un outil qui aide à l'interprétation des résultats significatifs, en fournissant une mesure de la force d'un résultat. L'indice de fragilité représente le nombre d'événements consécutifs qui doivent être ajoutés à un résultat dichotomique pour que le résultat ne soit plus significatif. Un petit nombre représente un résultat plus faible et un grand nombre un résultat plus fort.
Pourquoi cette étude était-elle nécessaire maintenant ?
Accelerated wound healing following total knee arthroplasty (TKA) is beneficial, allowing for the possibility of greater functional outcomes. Accordingly, there has been recent interest in researching methods to enhance healing following surgery, which has brought popularity to platelet concentrates and related products. The high concentration of growth factors sourced from platelets has been reported to enhance tissue repair and bone formation in a number of interventions. However, high quality clinical investigations to demonstrate efficacy of autologous blood platelet concentrate in TKA are still required.
Quelle était la principale question de recherche ?
In adult patients undergoing TKA, what is the effect of autologous blood platelet concentrate on wound healing, knee function, and analgesic requirement at 3 month follow-up?
- Wound closure during hospitalization did not significantly differ between the two groups (POD3: P=0.5, 95%CI 7% (-11% to 25%); POD4: P=0.4, 95%CI 9% (-30% to 10%)).
- By two weeks post-operatively, the number of patients with total wound closure was significantly greater in the control group (16/46) compared to the PRP group (4/36) (P=0.02, 95%CI -24% (-41% to 7%)).
- Pain reduction at 6 weeks approached significance favoring the control group (At rest: P=0.08; During walking: P=0.07). However, difference in pain between groups diminished at 3-month follow-up (At rest: P=0.8; During walking: P=0.9).
- Frequency of pain medication use was similar between groups at both 6-week (P=0.9) and 3-month (P=0.1) follow-up evaluations.
- Functional outcomes did not significantly differ between groups: ROM evaluation (In hospital (POD 2-4): P=0.7; 3 months: P=0.9), and WOMAC score (6 weeks: P=0.7; 3 months: P=0.4).
De quoi dois-je me souvenir en priorité ?
Spray application of platelet-rich plasma for total knee arthroplasty was not associated with any benefit in wound healing. Additionally, there was no beneficial effect of platelet-rich plasma treatment on pain, analgesia or functional outcome over 3-months.
Comment cela affectera-t-il les soins prodigués à mes patients ?
The findings of this study do not support the use of spray-applied autologous blood platelet concentrate in total knee arthroplasty due to the lack of efficacy in improving wound healing, pain, and function compared to control. Since there was significant loss of power to detect differences between groups as a result of the integration of two hospitals into one and the subsequent loss of data, results of this research should be considered only as indicative rather than conclusive.
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