Platelet-Rich Plasma Does Not Improve Pain or Cartilage Volume in Knee Osteoarthritis .
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Effect of Intra-articular Platelet-Rich Plasma vs Placebo Injection on Pain and Medial Tibial Cartilage Volume in Patients With Knee Osteoarthritis: The RESTORE Randomized Clinical Trial.
JAMA . 2021 Nov 23;326(20):2021-2030.Two hundred and eighty eight patients with mild to moderate knee osteoarthritis (OA) were randomized to receive 3 intra-articular injections of leukocyte-poor platelet-rich plasma (PRP, n=144) or a placebo injection (n=144). The primary outcomes of interest were subjective pain scores and percentage change in medial tibial cartilage volume. Secondary outcomes of interest evaluated pain, function, quality of life, global change and joint structures on imaging. There was no difference in the change in pain or change in medial tibial cartilage volume at 1 year follow-up. Of the 31 pre-specified secondary outcomes, there were no differences noted in 29 of them.
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