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Previous Ace Report The Efficacy of Pain Neuroscience Education in Patients After Total Knee Arthroplasty Next Ace Report Efficacy of Intra-Articular Platelet-Rich Plasma Compared With Placebo in Knee Osteoarthritis
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General Orthopaedics
Platelet-Rich Plasma and Its Analogs Do Not Improve Functional Outcomes After ACL Reconstruction
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Arthroscopy
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GENERAL ORTHOPAEDICS
Platelet-Rich Plasma and Its Analogs Do Not Clinically Improve Functional Outcomes 1 Year After Anterior Cruciate Ligament Reconstruction: A Meta-analysis of Randomized Controlled Trials.

OrthoEvidence Journal (OE Journal) - ACE Report

OE Journal. 2026;14(8):3 Arthroscopy. 2025 01-Dec;():. 10.1016/j.arthro.2025.06.031
Contributing Authors

PVP Pinho MLR Defante GM Oliveira JF Fagundes Júnior

Study Summary

Nine studies including 502 patients undergoing anterior cruciate ligament (ACL) reconstruction were included in this systematic review and meta-analysis comparing platelet-rich plasma (PRP) versus no PRP. Pooled outcomes of interest included International Knee Documentation Committee (IKDC) score, Lysholm score, and Tegner activity score at 12 months. PRP demonstrated a statistically significant improvement in IKDC score, but did not reach the minimal clinically important difference, and no significant differences were observed in Lysholm or Tegner scores. Overall, PRP did not provide clinically meaningful functional improvement at 1 year following ACL reconstruction.

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How to cite this ACE Report

OrthoEvidence. Platelet-Rich Plasma and Its Analogs Do Not Improve Functional Outcomes After ACL Reconstruction. OE Journal. 2026;14(8):3. Available from: https://myorthoevidence.com/AceReport/Show/platelet-rich-plasma-and-its-analogs-do-not-improve-functional-outcomes-after-acl-reconstruction

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