Platelet-Rich Plasma and Its Analogs Do Not Clinically Improve Functional Outcomes 1 Year After Anterior Cruciate Ligament Reconstruction: A Meta-analysis of Randomized Controlled Trials.
OrthoEvidence Journal (OE Journal) - ACE Report
Epub Ahead of Print
Arthroscopy. 2025 01-Dec;():. 10.1016/j.arthro.2025.06.031What this means for my practice?
PRP augmentation during ACL reconstruction does not result in clinically meaningful improvement in functional outcomes at 12 months despite small statistical differences in IKDC scores. Clinically, routine use of PRP for ACL reconstruction may not provide significant value in improving long-term functional recovery. Key limitations include heterogeneity in PRP preparation methods, graft types, rehabilitation protocols, and limited ability to evaluate long-term outcomes.
Study Summary
Nine studies including 502 patients undergoing anterior cruciate ligament (ACL) reconstruction were included in this systematic review and meta-analysis comparing platelet-rich plasma (PRP) versus no PRP. Pooled outcomes of interest included International Knee Documentation Committee (IKDC) score, Lysholm score, and Tegner activity score at 12 months. PRP demonstrated a statistically significant improvement in IKDC score, but did not reach the minimal clinically important difference, and no significant differences were observed in Lysholm or Tegner scores. Overall, PRP did not provide clinically meaningful functional improvement at 1 year following ACL reconstruction.
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