LSD-induced increases in social adaptation to opinions similar to one's own are associated with stimulation of serotonin receptors

この研究はインパクトが大きい可能性があると判断されました。 OEのAIによるハイインパクト指標は、論文が掲載されたジャーナルと論文自体の科学的内容の両方からのシグナルを統合することで、論文の影響力を推定します。 最先端の自然言語処理を用いて開発されたOEハイインパクトモデルは、ジャーナルのインパクトファクターのみよりも、研究の将来の引用実績をより正確に予測します。 これにより、臨床的に意義のある研究をより早く認識することができ、読者は将来の診療を形成する可能性が最も高い論文に焦点を当てることができます。

研究概要

Twenty-four healthy participants were included in this double-blind, randomized, counterbalanced, cross-over study investigating the effect of lysergic acid diethylamide (LSD) on social influence processing as well as the role of the serotonin system in these processes. Participants received three different combination treatment protocols (placebo plus placebo, placebo plus LSD, Ketanserin plus LSD) across three sessions with a washout period of at least two weeks between sessions. Subjective drug effects were assessed with the Altered States of Consciousness (5D-ASC) and Positive and Negative Affect Schedule (PANAS) questionnaires, and brain scans were obtained using fMRI while participants completed a social influence paradigm. Results reveal that LSD increases social adaptation but only if the opinions of others are similar to the individual’s own. These increases were also associated with increased activity in the medial prefrontal cortex. Additionally, pretreatment with Ketanserin fully blocked LSD-induced changes during feedback processing, indicating a key role of the 5-HT2A system in social feedback processing.