LSD-induced increases in social adaptation to opinions similar to one's own are associated with stimulation of serotonin receptors

Este estudio ha sido identificado como potencialmente de alto impacto. La métrica de alto impacto de OE, basada en la inteligencia artificial, estima la influencia que puede tener un artículo integrando señales procedentes tanto de la revista en la que se publica como del contenido científico del propio artículo. Desarrollado mediante el procesamiento del lenguaje natural más avanzado, el modelo de Alto Impacto de OE predice con mayor precisión el futuro rendimiento de las citas de un estudio que el factor de impacto de la revista por sí solo. Esto permite reconocer antes las investigaciones clínicamente significativas y ayuda a los lectores a centrarse en los artículos con más probabilidades de configurar la práctica futura.

Resumen del estudio

Twenty-four healthy participants were included in this double-blind, randomized, counterbalanced, cross-over study investigating the effect of lysergic acid diethylamide (LSD) on social influence processing as well as the role of the serotonin system in these processes. Participants received three different combination treatment protocols (placebo plus placebo, placebo plus LSD, Ketanserin plus LSD) across three sessions with a washout period of at least two weeks between sessions. Subjective drug effects were assessed with the Altered States of Consciousness (5D-ASC) and Positive and Negative Affect Schedule (PANAS) questionnaires, and brain scans were obtained using fMRI while participants completed a social influence paradigm. Results reveal that LSD increases social adaptation but only if the opinions of others are similar to the individual’s own. These increases were also associated with increased activity in the medial prefrontal cortex. Additionally, pretreatment with Ketanserin fully blocked LSD-induced changes during feedback processing, indicating a key role of the 5-HT2A system in social feedback processing.