LSD-induced increases in social adaptation to opinions similar to one's own are associated with stimulation of serotonin receptors
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(12):62 Sci Rep. 2020 23-Feb;():. 10.1038/s41598-020-68899-yWhat this means for my practice?
LSD increases social adaptation to the opinion of others, but only if they are similar to one’s own. During social feedback processing, LSD also increases activity in the medial prefrontal cortex. This processing may be dependent on the 5-HT2A receptor system as LSD-induced effects were blocked by Ketanserin. Additionally, the magnitude of LSD-induced changes in social adaptation is associated with personality factors. In particular, LSD may have a strong impact on participants with a tendency to negative and anxious affect. Future studies should investigate the role of other receptors on social feedback processes, the role of Ketanserin alone on social influence, and should include a non-social control to determine if the results are specific to social feedback or represent a more global change.
Study Summary
Twenty-four healthy participants were included in this double-blind, randomized, counterbalanced, cross-over study investigating the effect of lysergic acid diethylamide (LSD) on social influence processing as well as the role of the serotonin system in these processes. Participants received three different combination treatment protocols (placebo plus placebo, placebo plus LSD, Ketanserin plus LSD) across three sessions with a washout period of at least two weeks between sessions. Subjective drug effects were assessed with the Altered States of Consciousness (5D-ASC) and Positive and Negative Affect Schedule (PANAS) questionnaires, and brain scans were obtained using fMRI while participants completed a social influence paradigm. Results reveal that LSD increases social adaptation but only if the opinions of others are similar to the individual’s own. These increases were also associated with increased activity in the medial prefrontal cortex. Additionally, pretreatment with Ketanserin fully blocked LSD-induced changes during feedback processing, indicating a key role of the 5-HT2A system in social feedback processing.
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