Intramedullary Nailing Versus External Fixation in the Treatment of Open Tibial Fractures in Tanzania: Results of a Randomized Clinical Trial

この研究はインパクトが大きい可能性があると判断されました。 OEのAIによるハイインパクト指標は、論文が掲載されたジャーナルと論文自体の科学的内容の両方からのシグナルを統合することで、論文の影響力を推定します。 最先端の自然言語処理を用いて開発されたOEハイインパクトモデルは、ジャーナルのインパクトファクターのみよりも、研究の将来の引用実績をより正確に予測します。 これにより、臨床的に意義のある研究をより早く認識することができ、読者は将来の診療を形成する可能性が最も高い論文に焦点を当てることができます。

研究概要

Two-hundred and forty patients were randomized to receive intramedullary nailing or external fixation. The primary outcomes included incidence of re-operation for deep infection, non-union, and malalignment as well as the incidence of mortality. Secondary outcomes included quality of life through using EuroQol-5 Dimensions, 3 level questionnaire (EQ-5D-3L) and EQ-Visual Analog Scale (VAS), radiographic alignment, and healing. The EQ-5D-3L and EQ-VAS questionnaire data were collected at 2, 6, 12, 26, and 52 weeks. Radiographic healing was measured through the modified Radiographic Union Scale for Tibial fractures (mRUST) questionnaire in which data were collected at 6, 12, 26, and 52 weeks. Significant differences were not observed for the primary outcomes. However, coronal malalignment improved within the intramedullary nailing treatment group. Furthermore, quality of life as measured by EQ-5D-3L and EQ-VAS, improved at 6 weeks which did not continue through to the 1-year follow-up. Yet, radiographic fracture healing improved both at 6 and 12 weeks as well as 1-year follow-up.