Acute and post-acute behavioral and psychological effects of salvinorin A in humans

この研究はインパクトが大きい可能性があると判断されました。 OEのAIによるハイインパクト指標は、論文が掲載されたジャーナルと論文自体の科学的内容の両方からのシグナルを統合することで、論文の影響力を推定します。 最先端の自然言語処理を用いて開発されたOEハイインパクトモデルは、ジャーナルのインパクトファクターのみよりも、研究の将来の引用実績をより正確に予測します。 これにより、臨床的に意義のある研究をより早く認識することができ、読者は将来の診療を形成する可能性が最も高い論文に焦点を当てることができます。

研究概要

Thirty participants were included in this double-blind, within-group, crossover study evaluating the dose-related effects of salvinorin A. Participants were administered an active dose of salvinorin A (1,017μg) and a presumed non-psychoactive placebo dose (100μg) over two sessions with a washout period of two weeks between sessions. Physiological effects were measured using heart rate, blood pressure, temperature and respiratory rate. Behavioural effects were assessed using the observer-based Monitor Rating Questionnaire (MRQ) and subjective drug effects were assessed using participant ratings on the Hallucinogen Rating Scale (HRS). Lasting drug effects were assessed in follow-up interviews at 8-weeks. Study results indicate that participants talked, laughed, and moved more often on an active dose. The active dose also indicated hallucinogenic experiences on all 6 subscales of the HRS. No significant adverse events were observed or reported by participants.