Acute and post-acute behavioral and psychological effects of salvinorin A in humans

Este estudio ha sido identificado como potencialmente de alto impacto. La métrica de alto impacto de OE, basada en la inteligencia artificial, estima la influencia que puede tener un artículo integrando señales procedentes tanto de la revista en la que se publica como del contenido científico del propio artículo. Desarrollado mediante el procesamiento del lenguaje natural más avanzado, el modelo de Alto Impacto de OE predice con mayor precisión el futuro rendimiento de las citas de un estudio que el factor de impacto de la revista por sí solo. Esto permite reconocer antes las investigaciones clínicamente significativas y ayuda a los lectores a centrarse en los artículos con más probabilidades de configurar la práctica futura.

Resumen del estudio

Thirty participants were included in this double-blind, within-group, crossover study evaluating the dose-related effects of salvinorin A. Participants were administered an active dose of salvinorin A (1,017μg) and a presumed non-psychoactive placebo dose (100μg) over two sessions with a washout period of two weeks between sessions. Physiological effects were measured using heart rate, blood pressure, temperature and respiratory rate. Behavioural effects were assessed using the observer-based Monitor Rating Questionnaire (MRQ) and subjective drug effects were assessed using participant ratings on the Hallucinogen Rating Scale (HRS). Lasting drug effects were assessed in follow-up interviews at 8-weeks. Study results indicate that participants talked, laughed, and moved more often on an active dose. The active dose also indicated hallucinogenic experiences on all 6 subscales of the HRS. No significant adverse events were observed or reported by participants.