Safety, tolerability, pharmacokinetics, and pharmacodynamics of low dose lysergic acid diethylamide (LSD) in healthy older volunteers
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OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(11):30 Psychopharmacology (Berl). 2020 23-Feb;():. 10.1007/s00213-019-05417-7Study Summary
Forty-eight healthy subjects underwent a phase one double-blind, placebo-controlled randomized study to test the safety, tolerability, pharmacokinetics and pharmacodynamics of various oral doses of LSD. Subjects were randomly assigned to one of three dose groups (5, 10, or 20 micrograms) or a placebo and received that dose every four days for a total of six doses. LSD was well-tolerated , with no higher frequency of adverse events than placebo. There were no impairments in cognition, balance and proprioception.
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