Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial
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OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(11):31 J Psychopharmacol. 2016 23-Feb;():. 10.1177/0269881116675512Study Summary
Twenty-nine patients with cancer-related anxiety and depression underwent a double-blind, placebo-controlled crossover study to test the effects of psilocybin on cancer-related anxiety and depression. Patients randomly received either single-dose psilocybin (0.3 mg/kg) or a placebo. Primary outcome measures were anxiety and depression between groups. Prior to the crossover, psilocybin induced immediate, substantial and sustained improvements in anxiety and depression and led to decreases in cancer-related demoralization and hopelessness, improved spiritual well being and increased quality of life.
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