Psilocybin-assisted treatment for alcohol dependence: a proof-of-concept study
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(12):50 J Psychopharmacol. 2015 11-Apr;():. 10.1177/0269881114565144What this means for my practice?
Psilocybin used in conjunction with motivational enhancement therapy appears to decrease the number of drinking days and number of heavy drinking days in participants with alcohol dependence. With the results from this proof of concept study, future randomized controlled trials need to be conducted.
Study Summary
A single-group, pre-post psilocybin case series was conducted in 10 volunteers with DSM-IV diagnosed alcohol dependence. Patients received one or two doses of oral psilocybin in separate sessions alongside motivational enhancement therapy. Patients were assessed on the effects of psilocybin, as well as drinking abstinence, the Short Inventory of Problems (SIP), Penn Alcohol Craving Scale (PACS), Alcohol Abstinence Self-Efficacy Scale (AASE), and Profile of Mood States (POMS). In the first 4 weeks of treatment there was no significant increase in abstinence. Increases in abstinence were seen at weeks 5-8 through to week 36. The intensity of the effects of psilocybin were predictive of changes in drinking at weeks 5-8, with more intense experiences correlating to increased abstinence.
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