Effects of ayahuasca on sensory and sensorimotor gating in humans as measured by P50 suppression and prepulse inhibition of the startle reflex, respectively
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(12):51 Psychopharmacology (Berl). 2002 23-Feb;():. 10.1007/s00213-002-1237-5What this means for my practice?
Ayahuasca led to a dose-depended decrease in P50 suppression, with no effect on PPI. This indicates that ayahuasca may have a detrimental effect on sensory gating, with no effect on sensorimotor gating.
Study Summary
In a double blind, crossover randomized controlled trial 18 healthy participants were randomized at different sessions to either placebo, 0.6 mg DMT/kg or 0.85 mg DMT/kg. Participants underwent EEG assessment for the P50 auditory evoked potential (AEP), prepulse inhibition (PPI) of the startle reflex in order to assess sensory and sensorimotor gating, respectively. There was a significant dose-dependent reduction of P50 suppression after ayahuasca, while no significant differences were found in PPI, indicating a potential decremental effect of ayahuasca on sensory gating, but with no effect on sensorimotor gating.
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