Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study
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OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(12):49 Lancet Psychiatry. 2016 11-Apr;():. 10.1016/S2215-0366(16)30065-7Study Summary
In an open-label feasibility trial, 12 patients with moderate-to-severe treatment-resistant depression received two oral doses of psilocybin (10mg and 25mg) separated by 7 days. Patients were assessed on measures of drug effects at each session, and were also assessed on measures if depressive symptoms at baseline, 1 week and 3 months after the second psilocybin session. A significant increase in self-reported drug effects and the impaired cognition, anxiety, and global score of the 11D-ASC were seen during the drug sessions. When compared to baseline, depressive symptoms were significantly lower at 1 week and 3 months following the 25 mg session.
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