Prediction of psilocybin response in healthy volunteers
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Vol. 10 Iss. 11 | June 2022 | Number 40
PLoS One. 2012 23-Feb;():. 10.1371/journal.pone.0030800
Study Summary
A meta-analysis was completed to analyze the order of importance of 24 non-pharmacological predictor variables on psilocybin response in comparison to drug dose. The analysis involved pooled data of 23 controlled experimental studies with 409 psilocybin administrations to 261 healthy volunteers. Non-pharmacological variables contributing to psilocybin response included a high score on the Absorption personality trait, being in an emotionally excitable state immediately before drug intake, and experiencing few psychological problems in the past weeks. These were strongly associated with pleasant and mystical-type experiences.
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