Peripheral nerve block anaesthesia and postoperative pain in acute ankle fracture surgery: the AnAnkle randomised trial

この研究はインパクトが大きい可能性があると判断されました。 OEのAIによるハイインパクト指標は、論文が掲載されたジャーナルと論文自体の科学的内容の両方からのシグナルを統合することで、論文の影響力を推定します。 最先端の自然言語処理を用いて開発されたOEハイインパクトモデルは、ジャーナルのインパクトファクターのみよりも、研究の将来の引用実績をより正確に予測します。 これにより、臨床的に意義のある研究をより早く認識することができ、読者は将来の診療を形成する可能性が最も高い論文に焦点を当てることができます。

研究概要

One hundred and fifty patients scheduled for an acute ankle fracture surgery were randomized to receive peripheral nerve blockade (popliteal sciatic nerve block; saphenous nerve block; n=77) or spinal anesthesia (n=73). The primary outcome of interest was post-operative pain measured using the Pain Intensity and Opioid Consumption (PIOC) score, a composite of Numeric Pain Rating (NRS) area under the curve pain score and total morphine consumption. Secondary outcomes of interest included NRS area under the curve, morphine consumption, quality of recovery (QoR-15) score, opioid adverse events on the opioid related symptom distress score (OR-SDS), number of patients at risk of post-operative pain, patient satisfaction, and adverse events. Outcomes were assessed up to 27 hours post-operation. Results revealed significantly lower PIOC scores, morphine consumption, and NRS area under curve pain scores in the peripheral nerve block group compared to the spinal anesthesia group (p<0.05 for all). Moreover, the incidence of opioid adverse events on post-operative day 2 and the number of patients at risk of post-operative pain were significantly lower in the peripheral nerve block group (p=0.001). No significant differences in the incidence of adverse events were observed between the two groups (p=0.075).