Sixty-four adolescent patients scheduled for a posterior spinal fusion surgery were randomized to receive peri-operative oral pregabalin or placebo for the reduction of pain and opioid consumption post-operation. The primary outcomes of interest were oxycodone cumulative consumption and oxycodone consumption rate. Secondary outcomes of interest included pain scores on the Scoliosis Research Society (SRS) 24 scale and verbal numeric rating scale (NRS), the use of rescue analgesia and length of stay. Additionally, adverse events were reported. A sub-group analysis of patients with adolescent idiopathic scoliosis was performed. Results of the study found no significant differences between the pregabalin and placebo group in all outcomes at all time-points. Results of the sub-group analysis were similar.