Clinical effects of intraarticular injection of high molecular weight hyaluronan (Orthovisc) in osteoarthritis of the knee: a randomized, controlled, multicenter trial

Este estudio ha sido identificado como potencialmente de alto impacto. La métrica de alto impacto de OE, impulsada por la IA, estima la influencia que probablemente tendrá un artículo integrando señales tanto de la revista en la que se publica como del contenido científico del propio artículo. Desarrollado mediante el procesamiento del lenguaje natural más avanzado, el modelo de Alto Impacto de OE predice con mayor precisión el futuro rendimiento de las citas de un estudio que el factor de impacto de la revista por sí solo. Esto permite reconocer antes las investigaciones clínicamente significativas y ayuda a los lectores a centrarse en los artículos con más probabilidades de configurar la práctica futura.

372 patients with Kellgren-Lawrence grade I-III knee osteoarthritis (OA) were randomized to either four intra-articular injections of high-molecular-weight (HMW) hyaluronic acid (HA), three intra-articular injections of HMW HA and one control arthrocentesis, or four sessions of control arthrocentesis. The primary outcome was the percentage of patients demonstrating a minimum 20% relative reduction from baseline in WOMAC pain score. Follow-up was conducted at 8, 12, 16, and 22 weeks after the first treatment session. All groups demonstrated a significant improvement from baseline in pain measures, and there were no significant between-group differences in the degree of pain reduction throughout follow-up. The four-injection HA group demonstrated a significantly higher rate of patients demonstrating a minimum reduction of 20% in WOMAC pain at 8 weeks, but not at any subsequent follow-up time points. At no time point did the three-injection HA group demonstrate a significantly higher rate than the control group for the primary outcome. Patients with Kellgren-Lawrence grade I knee OA severity were removed from the primary outcome analysis that was presented, and left group sizes below the a priori sample size calculation.