Differences in hyaluronic acid characteristics influence outcomes in knee OA patients .
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Product Differences in Intra-articular Hyaluronic Acids for Osteoarthritis of the Knee
Am J Sports Med. 2016 Aug;44(8):2158-6568 randomized controlled studies evaluating the effects of intra-articular hyaluronic acid injections in patients with knee osteoarthritis were selected for inclusion. The purpose of this meta-analysis was to compare the safety and efficacy of differing hyaluronic acid preparations for the treatment of knee osteoarthritis. The results displayed the greatest pain efficacy in high-molecular-weight hyaluronic acid products, yet this group also had significantly more flare-ups when compared to other treatments. High-molecular-weight preparations were correlated with less discontinuation due to adverse events, and biological fermentation-derived hyaluronic acid was associated with a superior safety profile compared to avian-derived hyaluronic acid.
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