Effect of High-Intensity Strength Training on Knee Pain and Knee Joint Compressive Forces for KOA .
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Effect of High-Intensity Strength Training on Knee Pain and Knee Joint Compressive Forces Among Adults With Knee Osteoarthritis: The START Randomized Clinical Trial
JAMA . 2021 Feb 16;325(7):646-657.Three hundred seventy-seven adults with knee osteoarthritis were randomized to receive high-intensity strength training (n=127), low-intensity strength training (n=126), or attention control (n=124). The primary outcomes were knee pain measured by the WOMAC scale and knee joint compressive force during walking. Secondary outcomes included physical function, 6-minute walk distance, joint space width, thigh muscle and fat volume, inflammatory markers, and muscle strength. Outcomes were assessed at 6 and 18 months. Overall, the results of the study revealed no statistically significant differences in primary outcomes between high-intensity training and either low-intensity or control groups. The findings suggest that high-intensity strength training does not confer additional benefit in pain or mechanical load reduction compared to lower-intensity alternatives.
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