Resumo do estudo

Three hundred seventy-seven adults with knee osteoarthritis were randomized to receive high-intensity strength training (n=127), low-intensity strength training (n=126), or attention control (n=124). The primary outcomes were knee pain measured by the WOMAC scale and knee joint compressive force during walking. Secondary outcomes included physical function, 6-minute walk distance, joint space width, thigh muscle and fat volume, inflammatory markers, and muscle strength. Outcomes were assessed at 6 and 18 months. Overall, the results of the study revealed no statistically significant differences in primary outcomes between high-intensity training and either low-intensity or control groups. The findings suggest that high-intensity strength training does not confer additional benefit in pain or mechanical load reduction compared to lower-intensity alternatives.