Intramedullary Nail- Versus Plate- Fixation for Humeral Fractures: A Review of Outcomes by Fracture Location .

Choosing between intramedullary nailing and plate fixation for humeral fractures remains a subject of intense debate in orthopaedic surgery. In this review, randomized trial evidence is evaluated, comparing these fixation strategies for proximal, shaft, and distal humeral fractures. By systematically reviewing outcomes such as fracture union, reoperation rates, and adverse events, the report examines whether anatomical location should influence surgical decision-making. With mixed findings across RCTs and conflicting signals from observational studies, the evidence landscape remains nuanced—highlighting the need for individualized clinical judgment and further high-quality research.