OE JOURNAL

OE Journal

Vol. 6 | Iss. 19 | October 2018 - 41 Studies

ORIGINAL ANALYSIS

Medical Cannabis for treatment of Chronic Non-Cancer Pain – What’s the state of the Evidence?

Cannabinoids as an option for chronic non-cancer pain has grown in interest alongside concerns about opioid-related harms. A broad review of randomized trials and comparative studies revealed diverse international research exploring oral, inhaled, and oromucosal formulations across conditions such as neuropathy, multiple sclerosis, and spinal cord injury. Findings were mixed: while many studies reported pain reduction, a substantial proportion showed no clear benefit, underscoring variability in treatment response and study quality. The evidence base remains heterogeneous, setting the stage for pooled analyses to better clarify the true analgesic effect.

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Medical Cannabis for treatment of Chronic Non-Cancer Pain – What’s the state of the Evidence?

California Orthopaedic Association 2018 - Outpatient Total Knee Arthroplasty

Arthroplasty 8

No apparent benefit of PSI over standard instrumentation for clinical or radiological outcome in TKA

Knee Surg Sports Traumatol Arthrosc. 2018 Sep;26(9):2788-2796. doi: 10.1007/s00167-017-4741-1

AAOS2018: Tourniquet versus tourniquetless total knee arthroplasty

No clear benefit of liposomal bupivacaine over plain bupivacaine for periarticular injection in TKA

J Arthroplasty. 2018 Aug;33(8):2460-2464 doi: 10.1016/j.arth.2018.03.014

No analgesic advantage of liposomal bupivacaine over ropivacaine for infiltration analgesia in TKA

J Arthroplasty. 2018 Aug;33(8):2455-2459. doi: 10.1016/j.arth.2018.02.083

Comparing femoral component rotation and intercompartmental force differences between GB and MR TKA

J Arthroplasty. 2018 Jul;33(7S):S126-S130. doi: 10.1016/j.arth.2018.02.044

Influences of route of acetaminophen administration and periarticular liposomal bupivacaine in TKA

J Arthroplasty. 2018 Jul;33(7S):S136-S141. doi: 10.1016/j.arth.2018.02.088

Reduced two-year subsidence with short- versus conventional femoral stem in total hip arthroplasty

Bone Joint J. 2018 Sep;100-B(9):1148-1156. doi: 10.1302/0301-620X.100B9.BJJ-2017-1403.R1

Combined block of lateral cutaneous and subcostal nerves in THA no more effective than placebo

Acta Orthop. 2018 Jun;89(3):272-277

Cannabis 8

Cannabis medicinal extract effective in improving some neurogenic symptoms - a pilot study

Clin Rehabil. 2003 Feb;17(1):21-9.

Nabilone reduces pain and improves sleep and quality of life in diabetic peripheral neuropathic pain

Pain. 2012 Oct;153(10):2073-82. https://dx.doi.org/10.1016/j.pain.2012.06.024

Nabilone well-tolerated, but weaker analgesic than dihydrocodeine for neuropathic pain

BMJ. 2008 26-Jan;336(7637):199-201. http://dx.doi.org/10.1136/bmj.39429.619653.80

9.4% THC improves neuropathic pain and quality of life compared to placebo over 5 days

Send to CMAJ. 2010 Oct 5;182(14):E694-701. doi: 10.1503/cmaj.091414

Tetrahydrocannabinol similar in efficacy & safety as placebo in improving spasticity and pain in MS

Clin Ther. 2018 Sep;40(9):1467-1482. doi: 10.1016/j.clinthera.2017.01.016

Adding smoked cannabis to concomitant analgesics reduce medically refractory pain in HIV patients

Neuropsychopharmacology. 2009 February;34(3):672-680. http://dx.doi.org/10.1038/npp.2008.120

Dronabinol improves chronic non-cancer pain when added to standard opioid therapy

J Pain. 2008 Mar;9(3):254-64

Delta 9-THC has better analgesic effect compared to placebo for neuropathic pain over 8 hours

J Pain. 2016 Sep;17(9):982-1000. doi: 10.1016/j.jpain.2016.05.010

Foot & Ankle 5

Better function, pain, and reduction with suture button vs screw fixation for syndesmotic injury

J Bone Joint Surg Am. 2018 Jan 3;100(1):2-12

Percutaneous versus open repair of acute Achilles tendon rupture

Foot Ankle Int. 2018 Jun;39(6):689-693

Similar 6-mo results between PRP and stromal vascular fraction injections for Achilles tendinopathy

Knee Surg Sports Traumatol Arthrosc. 2018 Jul;26(7):2000-2010

Assessing the clinical effect of low-level laser therapy added to usual care for plantar fasciitis

Lasers Med Sci. 2018 Jul;33(5):949-958. doi: 10.1007/s10103-017-2423-3

Post-Achilles tendon repair elongation unaffected by weightbearing protocol used after surgery

Am J Sports Med. 2018 Aug;46(10):2492-2502. doi: 10.1177/0363546518781826

General Orthopaedics 2

Bone marrow concentrate implantation alongside decompression of no benefit in ONFH treatment

Int Orthop. 2018 Jul;42(7):1429-1435. doi: 10.1007/s00264-017-3650-8. Epub 2017 Oct 7

VitD supplementation, with or without calcium, does not reduce fracture rate in community adults

JAMA. 2018 Apr 17;319(15):1600-1612

Hand & Wrist 4

Comparison of no orthosis, removable orthosis, and plaster cast after miniopen carpal tunnel release

J Hand Surg Am. 2018 Aug;43(8):775.e1-775.e8. doi: 10.1016/j.jhsa.2018.01.016

90-day and 1-year cost estimates of ORIF versus percutaneous pinning for displaced DRF

J Bone Joint Surg Am. 2018 May 2;100(9):786-792

Similar rate of success in Dupuytren contracture treatment between collagenase and needle fasciotomy

J Bone Joint Surg Am. 2018 Jul 5;100(13):1079-1086

No significant difference for improvement of erosive hand OA pain between adalimumab and placebo

Osteoarthritis Cartilage. 2018 Jul;26(7):880-887. doi: 10.1016/j.joca.2018.02.899

Metabolic Disorders 1

Zoledronic Acid, alendronate, and risedronate reduce vertebral, nonvertebral, and hip fracture

Osteoporos Int. 2016 Nov;27(11):3289-3300

Osteoarthritis 1

Topical flaxseed oil versus placebo for treatment of knee osteoarthritis

Complement Ther Clin Pract. 2018 May;31:302-307

Pediatric Orthopaedics 1

Comparing ketamine plus atropine vs ketamine alone for pediatric procedural sedation

Am J Emerg Med. 2018 Jul;36(7):1280-1286. doi: 10.1016/j.ajem.2018.04.010

Physical Therapy & Rehab 3

Comparison of 8-week programs of treadmill, cycle ergometer, and arm ergometer exercise for knee OA

Phys Ther Sport. 2018 Jul;32:22-28. doi: 10.1016/j.ptsp.2018.04.001

Assessment of corticosteroid injection with and without hydrodilatation for adhesive capsulitis

PM R. 2018 Jun;10(6):623-635

Varus stress radiographs similar after 6 months between early and delayed weightbearing after FCLR

Am J Sports Med. 2018 Aug;46(10):2355-2365. doi: 10.1177/0363546518784301

Shoulder & Elbow 1

Decompression of no statistical benefit over sham, and no clinical benefit over exercise for SIS

BMJ. 2018 Jul 19;362:k2860. doi: 10.1136/bmj.k2860

Spine 1

Total disc replacement improves outcomes compared to ACDF for degenerative cervical disc disease

Bone Joint J. 2018 Aug;100-B(8):991-1001. doi: 10.1302/0301-620X.100B8.BJJ-2018-0120.R1

Sports Medicine 1

PRP injection more effective than corticosteroid injection after 12 weeks for gluteal tendinopathy

Am J Sports Med. 2018 Mar;46(4):933-939

Trauma 3

Cement augmentation of PFNA for trochanteric fracture has no significant effect on early function

Injury. 2018 Aug;49(8):1436-1444. doi: 10.1016/j.injury.2018.04.022

Improvement in disability did not significantly differ between 3D and 2D planning for DRF malunion

J Bone Joint Surg Am. 2018 Jul 18;100(14):1191-1202

Outcomes of distraction osteogenesis unaltered by low intensity pulsed ultrasound therapy

J Orthop Surg Res. 2018 Aug 17;13(1):205. doi: 10.1186/s13018-018-0907-x

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OE JOURNAL

OE Journal

Vol. 6 | Iss. 19 | October 2018 - 41 Studies

ORIGINAL ANALYSIS

Medical Cannabis for treatment of Chronic Non-Cancer Pain – What’s the state of the Evidence?

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Overview

Editor's Pick

Questions

Full Issue

OE JOURNAL

OE Journal

Vol. 6 | Iss. 19 | October 2018 - 41 Studies

ORIGINAL ANALYSIS

Medical Cannabis for treatment of Chronic Non-Cancer Pain – What’s the state of the Evidence?

Full Issue Content

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