Tramadol-paracetamol for postoperative pain after spine surgery - A randomized, double-blind, placebo-controlled study.

研究概要

Back pain is a significant global health burden and a leading cause of disability. Spine surgery is often necessary for patients with severe cases, and efficient postoperative pain management is critical for recovery. Tramadol-paracetamol is proposed as a safer alternative to pure opioids, with potential benefits in reducing nociceptive and neuropathic pain. However, its efficacy and safety in spine surgery have not been established, creating a critical gap in evidence, especially given the growing emphasis on multimodal pain management and the opioid epidemic