Exercise, manual therapy, and use of booster sessions in physical therapy for knee osteoarthritis: a multi-center, factorial randomized clinical trial

この研究はハイインパクトの可能性があります。 OEのAI駆動型ハイインパクト指標は、論文が掲載されたジャーナルと論文自体の科学的内容の両方からのシグナルを統合することで、論文が持つ可能性の高い影響力を推定します。 最先端の自然言語処理を用いて開発されたOEハイインパクトモデルは、ジャーナルのインパクトファクターのみよりも、研究の将来の引用実績をより正確に予測します。 これにより、臨床的に意義のある研究をより早く認識することが可能になり、読者は将来の診療を形成する可能性が最も高い論文に集中することができます。

300 patients with knee osteoarthritis were included in this 2x2 factorial randomized controlled trial. The objective of this trial was 2-fold; 1) determine if the addition of manual therapy to exercise therapy provided improvements in pain and function outcomes, and 2) determine if the use of booster sessions sustained the improvements observed at the short-term follow-up. Patients were randomized into 4 groups; 1) exercise therapy for 9 weeks with no booster sessions, 2) exercise and manual therapy for 9 weeks with no booster sessions, 3) exercise therapy for 9 weeks with booster sessions, or 4) exercise and manual therapy for 9 weeks with booster sessions. There were no differences between groups in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) at 1 year. Manual therapy was associated with a transient effect of improving outcome on the WOMAC and the likelihood of being a treatment responder within the first 9 weeks, though these were not sustained at 12 months. The only significant effect observed with booster sessions was a significantly increased likelihood of being a treatment responder at 12 months.