Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(10):21 J Psychopharmacol. 2016 23-Feb;():. 10.1177/0269881116675513What this means for my practice?
A moderately high dose of psilocybin can decrease symptoms of depression and anxiety and increase quality of life in cancer patients. Additionally, patients in the high dose group reported positive changes in attitudes about life, with an increased wellbeing and decreased death anxiety. All these results were sustained at the six-month follow-up. These results are limited by the homogeneity and small size of the sample.
Study Summary
Fifty-one cancer patients with life-threatening depression and anxiety symptoms underwent a randomized, double-blind cross-over trial. Patients first received either a very low dose (1 or 3 mg/70 kg, n = 27) or high dose (22 or 30 mg/70 kg, n = 29) of psilocybin with five weeks in between sessions and a follow-up at six months. The primary therapeutic outcome measures were clinician-rated measures of depression and anxiety. The high dose group demonstrated decreased measures of depression and anxiety.
Unlock the Full ACE Report
You have access to 4 more FREE articles this month.
Click below to unlock and view this ACE Reports
Unlock Now
Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
Exclusive access to original content articles, including in-house systematic reviews, and articles on health research methods and hot orthopaedic topics
Or upgrade today and gain access to all OrthoEvidencecontent for as little as $1.99 per week.
Already have an account? Log in
Are you affiliated with one of our partner associations?
Click here to gain complimentary access as part your association member benefits!
0 of 4 monthly FREE articles unlocked
