Psilocybin-Induced Decrease in Amygdala Reactivity Correlates with Enhanced Positive Mood in Healthy Volunteers
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(10):22 Biol Psychiatry. 2015 23-Feb;():. 10.1016/j.biopsych.2014.04.010What this means for my practice?
With task-induced activation in the amygdala, psilocybin reduced the activation to negative and neutral pictures and this effect was stronger in the right amygdala. Psilocybin also increased subjective reports of positive mood and did not increase anxiety. Most importantly, the effect of psilocybin on amygdala reactivity was most strongly associated with positive mood change. There was no evidence of psilocybin specifically reducing amygdala reactivity in response to negative pictures. The results are limited by the use of healthy subjects, as psilocybin may not show similar effects in patients with depression.
Study Summary
Twenty-five healthy subjects underwent a double-blind, randomized placebo-controlled, cross-over design fMRI study to test the acute effects of psilocybin on amygdala reactivity to negative stimuli. Subjects received psilocybin and a placebo in two separate sessions fourteen days apart, and completed an amygdala reactivity task during the fMRI. Outcome measures included mood changes using the PANAS and the state portion of the STAI. Compared to the placebo, the psilocybin dose had reduced amygdala reactivity to negative and neutral stimuli. The reduction in reactivity was correlated with the psilocybin-induced increase in positive mood state.
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