This systematic review and meta-analysis included 21 studies comprising 1,356 patients diagnosed with plantar fasciitis comparing platelet-rich plasma (PRP) therapy versus other conservative treatments. Pooled outcomes of interest were pain (visual analog scale, VAS), plantar fascia thickness (PFT), foot function (Foot Function Index, FFI), and functional scores (American Orthopaedic Foot and Ankle Society, AOFAS). PRP showed significantly greater reductions in pain scores compared to ESWT, CSI, and placebo, and it improved AOFAS scores more than CSI and placebo. However, no consistent superiority was observed in PFT and FFI outcomes. These findings suggest PRP is a promising option for pain and functionality improvements in plantar fasciitis, although standardization of PRP protocols is needed.