Efficacy of Platelet-Rich Plasma for Chronic Lateral Ankle Instability After Modified Broström-Gould surgery: A Randomized, Single-Blinded, Prospective Controlled Trial.
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2023;11(11):3 Foot Ankle Orthop. 2023 Apr; 8(2): 24730114231168633.What this means for my practice?
Adding 3 platelet-rich plasma injections to conventional post-operative management did not provide a significant improvement in pain or function scores up to 6 months post-operation, but did reduce the decrease in range of motion at 3 months compared to conventional post-operative management only. This study was limited by the lack of a placebo group, the small sample size, and the short follow-up. Future studies including sham controlled injections and exploring other dosing regimens is of interest.
Study Summary
40 patients with chronic lateral ankle instability undergoing a modified Brostrom-Gould procedure were randomized to receive conventional post-operative management only (n=20) or in addition to 3 post-operative injections of leukocyte-rich platelet-rich plasma injections (PRP; n=20). Outcomes of interest included pain on a Visual Analog Scale (VAS), American Orthopaedic Foot & Ankle Society (AOFAS) scores, and total ankle range of motion, assessed up to 6 months post-operation (3 months for range of motion). PRP injections did not provide any significant benefit with respect to the improvement in pain or functional scores compared to the control group. However, the change from baseline in range of motion at 3 months was significantly in favour of the PRP group.
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