A randomized controlled trial of oxycodone/acetaminophen versus acetaminophen alone for emergency department patients with musculoskeletal pain refractory to ibuprofen.

研究概要

Of the 393 acute musculoskeletal pain patients who received 600mg ibuprofen, 154 were unresponsive and were subsequently randomized to receive oral oxycodone/acetaminophen (n=77) or acetaminophen alone (n=77) for pain relief. The primary outcome of interest was the improvement in pain scores on a 0-10 point scale 2 hours post-treatment. Secondary outcomes included adequacy of analgesia, satisfaction with medication, and medication-induced adverse events. Results revealed significantly greater improvement in pain scores with oxycodone/acetaminophen vs. acetaminophen alone. No significant differences in satisfaction were observed. The rate of medication related adverse events was higher in the oxycodone/acetaminophen group vs. acetaminophen alone group (34% vs. 9%).