Oxycodone/Acetaminophen vs. Acetaminophen Alone for Musculoskeletal Pain Refractory to Ibuprofen .
A randomized controlled trial of oxycodone/acetaminophen versus acetaminophen alone for emergency department patients with musculoskeletal pain refractory to ibuprofen.
Acad Emerg Med. 2021;28: 859–865.Of the 393 acute musculoskeletal pain patients who received 600mg ibuprofen, 154 were unresponsive and were subsequently randomized to receive oral oxycodone/acetaminophen (n=77) or acetaminophen alone (n=77) for pain relief. The primary outcome of interest was the improvement in pain scores on a 0-10 point scale 2 hours post-treatment. Secondary outcomes included adequacy of analgesia, satisfaction with medication, and medication-induced adverse events. Results revealed significantly greater improvement in pain scores with oxycodone/acetaminophen vs. acetaminophen alone. No significant differences in satisfaction were observed. The rate of medication related adverse events was higher in the oxycodone/acetaminophen group vs. acetaminophen alone group (34% vs. 9%).
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