Of the 393 acute musculoskeletal pain patients who received 600mg ibuprofen, 154 were unresponsive and were subsequently randomized to receive oral oxycodone/acetaminophen (n=77) or acetaminophen alone (n=77) for pain relief. The primary outcome of interest was the improvement in pain scores on a 0-10 point scale 2 hours post-treatment. Secondary outcomes included adequacy of analgesia, satisfaction with medication, and medication-induced adverse events. Results revealed significantly greater improvement in pain scores with oxycodone/acetaminophen vs. acetaminophen alone. No significant differences in satisfaction were observed. The rate of medication related adverse events was higher in the oxycodone/acetaminophen group vs. acetaminophen alone group (34% vs. 9%).