Matrix-associated Autologous Chondrocyte Implant vs. Periosteal Flap Implant .
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Autologous chondrocyte implantation using the original periosteum-cover technique versus matrix-associated autologous chondrocyte implantation: a randomized clinical trial
Am J Sports Med. 2010 May;38(5):924-33. Epub 2009 Dec 421 patients with symptomatic isolated full-thickness cartilage defects (4.1 +/- 0.09 cm2) at the femoral condyle were randomized to undergo either the matrix-associated autologous chrondocyte implantation (m-ACI) or periosteal flap autologous chrondocyte implantation (ACI-P). At 1 and 2 years follow up, the cartilage repair via matrix-associated autologous chondrocyte implant (m-ACI) was found equivalent in efficacy compared to earlier generation autologous chondrocyte implantation using periosteal flap technique.
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