Lysergic acid diethylamide (LSD-25) and schizophrenic reactions. A comparative study
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(12):12 J Nerv Ment Dis. 1968 23-Feb;():. 10.1097/00005053-196808000-00008What this means for my practice?
Undifferentiated schizophrenics had lower scores than the paranoid patents, but their responses did not resemble those of the LSD group. There were similar responses between the paranoid patients and the LSD group in terms of feelings of unreality, loss of controls, and changes in meanings of experiences and suspiciousness. The subjective comments of both the paranoid patients and the LSD subjects showed that their reactions were similar. These results show that both schizophrenia and LSD induce altered states of consciousness while also showing that symptoms can both overlap and differ between subjects. Predrug personalities can also affect responses. The results are limited by the use of all males.
Study Summary
Fifty healthy subjects underwent a double-blind, placebo-controlled study to compare the effects of LSD on these subjects to symptoms of schizophrenic patients. For the fifty healthy subjects, thirty received LSD while twenty received placebo. Questionnaires assessed the effects of LSD on perception, memory, imagery, and cognition. The schizophrenic patients, ten of which were paranoid and the other ten undifferentiated, also received this questionnaire. The undifferentiated schizophrenics had lower scores than the paranoid patients, but the responses did not resemble the LSD group. The responses of paranoid patients resembled the LSD group.
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