Leukocytes Do Not Influence the Safety and Efficacy of Platelet-Rich Plasma Injections for the Treatment of Knee Osteoarthritis: A Double-Blind Randomized Controlled Trial.

この研究はインパクトが大きい可能性があると判断されました。 OEのAIによるハイインパクト指標は、論文が掲載されたジャーナルと論文自体の科学的内容の両方からのシグナルを統合することで、論文の影響力を推定します。 最先端の自然言語処理を用いて開発されたOEハイインパクトモデルは、ジャーナルのインパクトファクターのみよりも、研究の将来の引用実績をより正確に予測します。 これにより、臨床的に意義のある研究をより早く認識することができ、読者は将来の診療を形成する可能性が最も高い論文に焦点を当てることができます。

研究概要

One hundred thirty-two patients with Kellgren-Lawrence grade 1-3 knee osteoarthritis were randomized to receive three weekly intra-articular injections of either LR-PRP (n=66) or LP-PRP (n=66). The primary outcome was the change in the International Knee Documentation Committee (IKDC) subjective score at 12 months. Secondary outcomes included pain, function, and quality of life assessed through various scales (KOOS, WOMAC, VAS, EQ-5D, Tegner activity scale), as well as objective measures such as range of motion and quadriceps circumference. Outcomes were evaluated at baseline and at 2, 6, and 12 months. Overall, both groups showed significant improvement in subjective and objective outcomes, with no significant differences except for a transient greater improvement in IKDC at 2 months in the LR-PRP group, and minor differences in ROM and quadriceps circumference at specific time points. No severe adverse events were reported, and the rate of treatment failure was similar. The study concluded that leukocytes did not influence the safety or efficacy of PRP injections for knee OA.