One hundred thirty-two patients with Kellgren-Lawrence grade 1-3 knee osteoarthritis were randomized to receive three weekly intra-articular injections of either LR-PRP (n=66) or LP-PRP (n=66). The primary outcome was the change in the International Knee Documentation Committee (IKDC) subjective score at 12 months. Secondary outcomes included pain, function, and quality of life assessed through various scales (KOOS, WOMAC, VAS, EQ-5D, Tegner activity scale), as well as objective measures such as range of motion and quadriceps circumference. Outcomes were evaluated at baseline and at 2, 6, and 12 months. Overall, both groups showed significant improvement in subjective and objective outcomes, with no significant differences except for a transient greater improvement in IKDC at 2 months in the LR-PRP group, and minor differences in ROM and quadriceps circumference at specific time points. No severe adverse events were reported, and the rate of treatment failure was similar. The study concluded that leukocytes did not influence the safety or efficacy of PRP injections for knee OA.