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LSD induced globally increased thalamocortical rFC compared to placebo. The subjective drug effect ratings of 'visionary restructuralization' and 'auditory alterations' significantly correlated with rFC measures between the thalamus and the right fusiform gyrus and insula. These findings suggest that hallucinogenic drug effects may be provoked by facilitations of cortical excitability via thalamocortical interactions. Overall, these findings provide implications for understanding the mechanism of action of hallucinogenic drugs. The results are limited by the small sample size, the absence of dose-response data and that ratings on subjective drug effects did not correspond to the duration of the fMRI scan exclusively.